Use of Verdye (ICG) in\u00a0<\/h1>Liver<\/h1>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tLearn More<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\tWith primary liver cancer and colorectal liver metastases amongst the most common leading causes of cancer-related deaths worldwide, surgery represents one of the main treatments to obtain the best results in overall and disease free survival.1<\/sup><\/p>\nVerdye (Indocyanine Green, ICG) in recent years has experienced increased interest in use for its clearance parameters as a dynamic
assessment of liver function both in medical and surgical settings.2<\/sup><\/p>\nICG is used routinely to evaluate hepatic function and liver blood flow.3<\/sup> It is one of the most common and easy-to-use tests for the perioperative dynamic assessment of liver function in cases of major liver surgery (resective surgery and liver transplantation) and in the intensive care unit.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\tUse of Verdye in Liver Function Diagnostics include:<\/span><\/h2>- Measurement of excretory function of the liver Measurement of liver blood flow<\/li>
- Verdye (Indocyanine Green (ICG)) is a tricarbocyanine dye with both hydrophilic and lipophilic properties.<\/li><\/ul><\/li><\/ul>
While numerous clinical parameters are used to assess a patient\u2019s liver function, the ICG test is the gold standard and is the only established test for estimating true global liver function.4<\/sup><\/p>Assessment of dynamic liver function is crucial in the pre-operative preparation of those who require extensive liver resections, liver transplants<\/a> and also to monitor liver function<\/a> in a post-operative setting.<\/p>The ICG clearance or the elimination test is the most widely used quantitative liver function test. Following the administration of ICG I.V., serial blood samples are collected at 5, 15, 20, 25 & 30 mins. The ICG blood levels fall exponentially for about 20mins, by which time approximately 97% of the ICG is excreted. After processing the samples, the ICG-R15 (at 15 mins) is determined as a percentage.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tLearn More<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t![\"ICG](\"https:\/\/diagnosticgreen.com\/row\/wp-content\/uploads\/sites\/2\/2020\/02\/diagnostic-green-verdye-vials.jpg\")
\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\tQUANTITATIVE MEASUREMENT<\/span><\/h4>\n\n \t- ICG Retention 15mins (ICG-R15) (Normal <10%)<\/li>\n \t
- Pulse Dye Densitometry \u2013 LiMON device<\/li>\n \t
- ICG Plasma Disappearance Rate (ICG-PDR)\n(Normal > 18%\/min)5<\/sup><\/li>\n<\/ul>\n
ICG CLEARANCE TESTS<\/h4>\n\n \t- Pre and post Liver Resections<\/li>\n \t
- Pre and post Liver Transplant Surgery<\/li>\n \t
- Acute Liver Failure (ICU setting)<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\t![\"https:\/\/diagnosticgreen.com\/wp-content\/uploads\/2020\/08\/Diagnostic-Green-Liver-Brochure-RoW.pdf\"](\"https:\/\/diagnosticgreen.com\/row\/wp-content\/uploads\/sites\/2\/2020\/09\/Colour_LiverCoverImage_Rezised.jpg\")
\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\tLAPAROSCOPIC LIVER RESECTION (LLR)<\/h3>
Since the first Laparoscopic Liver Resection<\/a> (LLR) was first preformed in 1991, the number of LLR\u2019s
has increased with the advancements of surgical techniques and technology. LLR for Hepatocellular<\/a>
Carcinoma (HCC) is now considered standard treatment for minor liver resection.6<\/sup> Laparoscopic
surgery and robotic surgery have solved the issue of large incisional wounds, a major drawback
of open liver surgery.7<\/sup> While there are significant advantages associated with a laparoscopic
technique (less bleeding, shorter length of hospital stay, decreased morbidity and possibly lower
mortality), adoption by a surgeon does mean that the ability to touch and palpate the organ is
eliminated. By using ICG in these circumstances, increasing the visualisation of the anatomy adds
enormously to procedure success.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\tVERDYE USE IN TREATMENT FOR HEPATOCELLULAR
CARCINOMA (HCC)<\/h3>
Over the last few decades, imaging technologies in hepatobiliary (HPB) surgery <\/a>have become indispensable tools for liver surgeons. The ICG<\/a> fluorescence imaging (FI) technique helps to guide the hepatic surgical procedures and provides the surgeon with real-time visualisation of the fluorescent structures of interest that would be invisible under conventional white light.<\/p>The extrahepatic bile duct anatomy and liver tumours can be emphasised, and hepatic segments highlighted, based on the fluorescence property of ICG and its biliary excretion.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t![\"verdye](\"https:\/\/diagnosticgreen.com\/row\/wp-content\/uploads\/sites\/2\/2020\/02\/diagnostic-green-verdye-how-its-supplied-1.jpg\")
\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\tCOLORECTAL LIVER METASTASES AND LIVER
TRANSPLANT USE OF ICG<\/h3>
With primary liver cancer and colorectal liver metastases amongst the most common leading causes of cancer-related deaths worldwide, surgery represents one of the main treatments to obtain the best results in overall and disease free survival.1<\/sup><\/p>\n Verdye (Indocyanine Green, ICG) in recent years has experienced increased interest in use for its clearance parameters as a dynamic ICG is used routinely to evaluate hepatic function and liver blood flow.3<\/sup> It is one of the most common and easy-to-use tests for the perioperative dynamic assessment of liver function in cases of major liver surgery (resective surgery and liver transplantation) and in the intensive care unit.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t While numerous clinical parameters are used to assess a patient\u2019s liver function, the ICG test is the gold standard and is the only established test for estimating true global liver function.4<\/sup><\/p> Assessment of dynamic liver function is crucial in the pre-operative preparation of those who require extensive liver resections, liver transplants<\/a> and also to monitor liver function<\/a> in a post-operative setting.<\/p> The ICG clearance or the elimination test is the most widely used quantitative liver function test. Following the administration of ICG I.V., serial blood samples are collected at 5, 15, 20, 25 & 30 mins. The ICG blood levels fall exponentially for about 20mins, by which time approximately 97% of the ICG is excreted. After processing the samples, the ICG-R15 (at 15 mins) is determined as a percentage.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t Since the first Laparoscopic Liver Resection<\/a> (LLR) was first preformed in 1991, the number of LLR\u2019s Over the last few decades, imaging technologies in hepatobiliary (HPB) surgery <\/a>have become indispensable tools for liver surgeons. The ICG<\/a> fluorescence imaging (FI) technique helps to guide the hepatic surgical procedures and provides the surgeon with real-time visualisation of the fluorescent structures of interest that would be invisible under conventional white light.<\/p> The extrahepatic bile duct anatomy and liver tumours can be emphasised, and hepatic segments highlighted, based on the fluorescence property of ICG and its biliary excretion.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
assessment of liver function both in medical and surgical settings.2<\/sup><\/p>\nUse of Verdye in Liver Function Diagnostics include:<\/span><\/h2>
\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\tQUANTITATIVE MEASUREMENT<\/span><\/h4>\n
\n \t
ICG CLEARANCE TESTS<\/h4>\n
\n \t
\t\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\tLAPAROSCOPIC LIVER RESECTION (LLR)<\/h3>
has increased with the advancements of surgical techniques and technology. LLR for Hepatocellular<\/a>
Carcinoma (HCC) is now considered standard treatment for minor liver resection.6<\/sup> Laparoscopic
surgery and robotic surgery have solved the issue of large incisional wounds, a major drawback
of open liver surgery.7<\/sup> While there are significant advantages associated with a laparoscopic
technique (less bleeding, shorter length of hospital stay, decreased morbidity and possibly lower
mortality), adoption by a surgeon does mean that the ability to touch and palpate the organ is
eliminated. By using ICG in these circumstances, increasing the visualisation of the anatomy adds
enormously to procedure success.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\tVERDYE USE IN TREATMENT FOR HEPATOCELLULAR
CARCINOMA (HCC)<\/h3>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\tCOLORECTAL LIVER METASTASES AND LIVER
TRANSPLANT USE OF ICG<\/h3>
![\"\"](\"https:\/\/diagnosticgreen.com\/row\/wp-content\/uploads\/sites\/2\/2020\/09\/Verdye-Vial-upclose-and-blurred-1024x213.jpg\")
\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t![\"graph](\"https:\/\/diagnosticgreen.com\/row\/wp-content\/uploads\/sites\/2\/2020\/08\/Italian-image.jpg\")
\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t![\"green-blue-wave\"](\"https:\/\/diagnosticgreen.com\/row\/wp-content\/uploads\/sites\/2\/2019\/04\/diagnostic-green-home-green-blue-wave-1.png\")
\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t