Please confirm your status to continue
By clicking “Yes,” you confirm that you are a licensed healthcare professional and acknowledge that this content is intended for professional use only and not intended for use by the general public.
Background –\u00a0\u00a0Anastomotic leakage (AL) is a severe postoperative complication in colorectal surgery, with an incidence up to 20% in rectal Near-infrared (NIR) fluorescence imaging with indocyanine green (ICG) is a technique that enables real-time assessment of intraoperative bowel perfusion. The aim of this study was to assess the clinical benefit of ICG NIR fluorescence bowel perfusion assessment in preventing AL.<\/p> Methods \u2013 This prospective, phase III, national multicentre randomised controlled trial included patients scheduled for laparoscopic or robotic colorectal surgery for benign and malignant diseases from eight participating hospitals in the Netherlands.\u00a0<\/p> Patient allocation into the Fluorescence Guided Bowel Anastomosis group (FGBA) or Conventional Bowel group (CBA) was conducted randomly.\u00a0<\/p> <\/p> <\/p> <\/p> <\/p> Findings – A total of 931 patients were\u00a0 included between 2 July 2020 and 21 February 2023 (FGBA group n=463: CBA-group n=481). The study population comprised of 485 (52.1%) men and 446 (47.9%) women.<\/p> Whilst the overall 90-day AL rate was not significantly different between FGBA and CBA groups, further exploration of specific sub-groups demonstrated a substantial reduction in AL rates among patients undergoing left sided and rectosigmoid resections.<\/p> <\/p><\/div> <\/p><\/div><\/div> Interpretation \u2013 Overall, the study unequivocally shows a statistically significant reduction in anastomotic leak rates when ICG is used for left sided colectomy.<\/strong><\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
resections. In its multifactorial aetiology, compromised bowel perfusion is considered a major contributing factor. Conventional perfusion assessment methods have a low predictive value for AL, highlighting the need for more accurate intraoperative diagnostic tests.<\/span><\/p>