Frequently
Asked Questions

Indocyanine Green has six hours of stability when reconstituted as detailed in the package insert. Diagnostic Green has no additional stability data beyond that.

IC-Green® (indocyanine green for injection) is an optical imaging agent indicated for:

• Fluorescence imaging of vessels (micro- and macro-vasculature), blood flow and tissue perfusion before, during and after vascular, gastrointestinal, organ transplant, plastic, micro- and reconstructive surgeries, including general minimally invasive surgical procedures, in adults and pediatric patients aged 1 month and older
• Fluorescence imaging of extrahepatic biliary ducts in adults and pediatric patients aged 12 years and older
• Fluorescence imaging of lymph nodes and lymphatic vessels during lymphatic mapping in adults with cervical and uterine cancer
• Ophthalmic angiography in adults and pediatric patients

IC Green® Injection (ICG) contains up to 5% sodium iodide.
Allergic reactions have been reported in patients with and without a history of allergy to iodides.
It is known that in very rare cases (<1/10,000), Indocyanine Green (ICG) can cause nausea and anaphylactic reactions.

With normal liver function, the plasma half-life of ICG is 3-4 minutes. Measurements can therefore be repeated after 15-20 minutes.

After injection, Indocyanine Green (ICG) fluorescence can be visualized in less than one minute.

Indicator-Dilution Studies.
Under sterile conditions, the IC-Green® Injection (ICG) powder should be dissolved with the Sterile Water provided and the solution used within 6 hours after it is prepared.

For visualization of vessels, blood flow and tissue perfusion (2.5mg/mL solution)

• 1.25 mg to 5 mg by intravenous injection is recommended for a surgical procedure in adults and pediatric patients aged 1 month and older. 
• 3.75 mg to 10 mg by intravenous injection is recommended for visualization of perfusion in extremities through the skin for plastic, micro-and reconstructive surgeries in adults. 
• Additional doses may be administered. Do not exceed a total dose of 2 mg/kg. 

For visualization of extrahepatic biliary ducts in adults and pediatric patients aged 12 years and older (2.5 mg/mL solution)

• 2.5 mg by intravenous injection at least 45 minutes prior to surgery. 
• Additional doses may be administered. Do not exceed a total dose of 2 mg/kg. 

For lymphatic mapping and cervical and uterine cancer in adults (1.25 mg/mL solution)

• 5 mg interstitially as four 1 mL injections. 

For ophthalmic angiography

• Doses up to 40 mg in 2 mL injections. 

The dosage depends on the intended application and the weight of the patient. For details, please see the instructions for use at

IC-Green® (indocyanine green for injection) Package Insert.

IC-Green® (indocyanine green for injection) Package configuration: available in vial kit of 6 vials of the lyophilized green powder and 6 vials of 10 mL Sterile Water for Injection, USP,  Vial Strength: 25 mg.

IC-Green® (indocyanine green for injection) is available as a 25 mL single-patient-use vial in a sterile (25 mg), lyophilized green powder for reconstitution

– for more information go to Product Information Leaflet IC-Green® (indocyanine green for injection) Package Insert.

No. IC-Green® (indocyanine green for injection) is a sterile product which is injected intravenously or interstitially. This medicinal product is for single use only.

After injection, Indocyanine Green (ICG) binds rapidly to plasma proteins, of which beta-apolipoprotein B is the principle carrier (95%). It is removed entirely through the liver and then eliminated through the bile. IC-Green® (indocyanine green for injection) is not metabolized or broken down.

Indocyanine Green for Injection (ICG) is approved for intravenous injection via an injection needle, a central or peripheral catheter or cardiac catheter and also interstitially for lymphatic mapping. 

 IC-Green® Injection (ICG) is a tricarbocyanine dye, is indicated:

• Fluorescence imaging of vessels (micro- and macro-vasculature), blood flow and tissue perfusion before, during and after vascular, gastrointestinal, organ transplant, plastic, micro- and reconstructive surgeries, including generally minimally invasive surgical procedures, in adults and pediatric patients aged 1 month and older
• Fluorescence imaging of extrahepatic biliary ducts in adults and pediatric patients aged 12 years and older
• Fluorescence imaging of lymph nodes and vessels during lymphatic mapping in adults with cervical and uterine cancer
• Ophthalmic angiography in adults and pediatric patients

IC-Green® (indocyanine green for injection)  is approved for use in the USA.

For more information on other territories where Diagnostic Green’s products are sold, please check out www.diagnosticgreen.com/ROW 

To report suspected adverse reactions:
contact us at 1-844-424-3784 or e-mail drugsafety@diagnosticgreen.com

The reconstituted solution should be used within six hours.  It is for single use only.  Discard any unused product.