Use of Indocyanine Green for Injection USP (ICG) in
ICGA is particularly useful in the differential diagnosis of Polypoidal Choroidal Vasculopathy (PCV), Central Serous Chorioretinopathy (CSCR), and Retinal Angiomatous Proliferation (RAP), which can be misdiagnosed as nAMD (Neovascular Age-related Macular Degeneration)1.
Key FeaturesIndocyanine Green for Injection USP (ICG)) is a tricarbocyanine dye with both hydrophilic and lipophilic properties.
The retention of ICG in the fenestrated choroidal circulation, combined with its low permeability, makes ICG angiography ideal for viewing the choroidal blood vessels.
Once injected, the ICG binds to plasma proteins and quickly circulates to the choroid layer, delineating the choroidal veins within 15-20 secs.
Indocyanine Green for Injection is cleared exclusively through the liver and then excreted through the bile. It does not undergo metabolism. Verdye has an excellent safety profile and adverse reactions occur very rarely (<1/10,000).
Using ICGA at initial presentation helps identify disorders of the choroidal circulation, allowing differential treatment approaches that may improve outcomes and safety for patients.
- Investigation of complex posterior uveitis and white dot syndromes
- Assessment of patients with “wet” AMD where the presence of polypoidal choroidal vasculopathy (PCV) is in question
- The assessment of choroidal hyperpermeability in patients with central serous chorioretinopathy
Indications for ICG Angiography Include:
- Choroidal Neovascularisation (CNV)
- Pigment Epithelial Detachment
- Polypoidal Choroidal Vasculopathy
- Retinal Angiomatous Proliferation (RAP)
- Central Serous Chorioretinopathy (CSCR)
- Intraocular Tumours
- Choroidal Inflammatory Conditions
Find out more from our FAQ page
ICGA vs OCTA
Note that all references are available in the Ophthalmic Brochure available to download