Thoracic surgeons utilizing minimally invasive techniques for lung nodule resection often rely on localization markers to determine precise nodule location intraoperatively. Transbronchial or transthoracic injection of indocyanine green (ICG) dye has become a popular technique. However, surgery must be performed immediately as dye will dissipate to surrounding tissue. This multicenter retrospective study evaluated the efficacy of CT guided transthoracic placement of ICG dye-soaked coils (CT ICG-C) for preoperative lung nodule localization. Nineteen adult patients with 21 nodules underwent CT ICG-C placement from 03/01/2023 until 02/28/2025 at two medical centers. There were no adverse events. Median time from localization to surgery was 1 day (IQR 0-4 days), with 57.1% undergoing surgery >24 hours later. Localization success rate was 100%. CT ICG-C is a novel technique that allows for accurate nodule localization, delayed surgical resection, and the preservation of healthy lung tissue.
