Frequently
Asked Questions

Indocyanine Green has six hours of stability when reconstituted as detailed in the package insert. Diagnostic Green has no additional stability data beyond that.

Indocyanine Green for Injection, USP, is a sterile, lyophilized green powder containing the active ingredient Indocyanine Green (ICG).

Following intravenous (I.V.) injection, ICG or Indocyanine Green binds rapidly to plasma proteins and remains within the blood vessels. It has a half-life of 3 to 4 minutes and is removed from circulation exclusively by the liver and then eliminated through the bile. It does not undergo metabolism.

Indocyanine Green (ICG) is dissolved using sterile water for injection and is for single use only.

Indocyanine Green for Injection, USP (ICG) contains up to 5% sodium iodide.
Allergic reactions have been reported in patients with and without a history of allergy to iodides.
It is known that in very rare cases (<1/10,000), Indocyanine Green (ICG) can cause nausea and anaphylactic reactions.

With normal liver function, the plasma half-life of ICG is 3-4 minutes. Measurements can therefore be repeated after 15-20 minutes.

After I.V. injection, Indocyanine Green (ICG) fluorescence can be visualized in less than one minute.

Indicator-Dilution Studies.
Under sterile conditions, the Indocyanine Green for Injection, USP powder should be dissolved with the Sterile Water for Injection, USP provided and the solution used within 6 hours after it is prepared.
The usual doses of Indocyanine Green for Injection USP for dilution curves are:
Adults 5.0 mg and Children – 2.5 mg, and Infants – 1.25 mg.

Hepatic Function Studies. 
Under sterile conditions, the Indocyanine Green for Injection, USP powder should be dissolved with the Sterile Water for Injection, USP provided. The patient should be weighed and the dosage calculated on the basis of 0.5 mg/kg of body weight. Exactly 5 mL of Sterile Water for Injection, USP should be added to the 25 mg vial giving 5 mg of dye per mL of solution.

Ophthalmic Angiography Studies. (2.3)
Dosages up to 40 mg Indocyanine Green for Injection, USP dye in 2 mL of Sterile Water for Injection, USP

The dosage depends on the intended application and the weight of the patient. For details, please see the instructions for use at Indocyanine Green for Injection, USP Package Insert.

Indocyanine Green for Injection, USP Package configuration: available in vial kit of 6 vials of the lyophilized green powder and 6 vials of 10 mL Sterile Water for Injection, USP,  Vial Strength: 25 mg.

Vials are available in 25mg. For more information go to the Product Information Leaflet Indocyanine Green for Injection, USP Package Insert.

No. Indocyanine Green for Injection, USP, (ICG) is a sterile product which is injected intravenously. This medicinal product is for single use only.

After I.V. injection, Indocyanine Green (ICG) binds rapidly to plasma proteins, of which beta-apolipoprotein B is the principle carrier (95%). It is removed entirely through the liver and then eliminated through the bile. Indocyanine Green for Injection, USP (ICG) is not metabolized or broken down.

Indocyanine Green for Injection (ICG) is approved for intravenous injection via an injection needle, a central or peripheral catheter or cardiac catheter.

Indocyanine Green for Injection, USP is a tricarbocyanine dye, is indicated:

• For determining cardiac output, hepatic function and liver blood flow. 

• For ophthalmic angiography. 

To find a Distributor or to check the availability of Indocyanine Green for Injection, USP (ICG) in your country please go to our Distributor section of the website

To report suspected adverse reactions:
contact us at 1-844-424-3784 or e-mail drugsafety@diagnosticgreen.com

Indocyanine Green for Injection (ICG) should be reconstituted immediately prior to use. It is for single use only.