Frequently
Asked Questions

Indocyanine Green has six hours of stability when reconstituted as detailed in the package insert. Diagnostic Green has no additional stability data beyond that.

IC-Green® (indocyanine green for injection) is an optical imaging agent indicated for:

• Fluorescence imaging of vessels (micro- and macro-vasculature), blood flow and tissue perfusion before, during and after vascular, gastrointestinal, organ transplant, plastic, micro- and reconstructive surgeries, including general minimally invasive surgical procedures, in adults and pediatric patients aged 1 month and older
• Fluorescence imaging of extrahepatic biliary ducts in adults and pediatric patients aged 12 years and older
• Fluorescence imaging of lymph nodes and lymphatic vessels during lymphatic mapping in adults with cervical and uterine cancer
• Ophthalmic angiography in adults and pediatric patients

IC Green® Injection (ICG) contains up to 5% sodium iodide.
Allergic reactions have been reported in patients with and without a history of allergy to iodides.
It is known that in very rare cases (<1/10,000), Indocyanine Green (ICG) can cause nausea and anaphylactic reactions. Always have cardiopulmonary resuscitation personnel and equipment readily available and monitor patients.

After injection, Indocyanine Green (ICG) fluorescence can be visualized in less than one minute.

Indicator-Dilution Studies.
Under sterile conditions, the IC-Green® Injection (ICG) powder should be dissolved with the Sterile Water provided and the solution used within 6 hours after it is prepared.

For visualization of vessels, blood flow and tissue perfusion (2.5mg/mL solution)

• 1.25 mg to 5 mg by intravenous injection is recommended for a surgical procedure in adults and pediatric patients aged 1 month and older. 
• 3.75 mg to 10 mg by intravenous injection is recommended for visualization of perfusion in extremities through the skin for plastic, micro-and reconstructive surgeries in adults. 
• Additional doses may be administered. Do not exceed a total dose of 2 mg/kg. 

For visualization of extrahepatic biliary ducts in adults and pediatric patients aged 12 years and older (2.5 mg/mL solution)

• 2.5 mg by intravenous injection at least 45 minutes prior to surgery. 
• Additional doses may be administered. Do not exceed a total dose of 2 mg/kg. 

For lymphatic mapping and cervical and uterine cancer in adults (1.25 mg/mL solution)

• 5 mg interstitially as four 1 mL injections. 

For ophthalmic angiography

• Doses up to 40 mg in 2 mL injections. 

The dosage depends on the intended application and the weight of the patient. For details, please see the instructions for use at

IC-Green® (indocyanine green for injection) Package Insert.

IC-Green® (indocyanine green for injection) Package configuration: available in vial kit of 6 vials of the lyophilized green powder and 6 vials of 10 mL Sterile Water for Injection, USP,  Vial Strength: 25 mg.

For injection: 25 mg of indocyanine green as a lyophilized, green powder for reconstitution in a single-patient-use vial.

– for more information go to Product Information Leaflet IC-Green® (indocyanine green for injection) Package Insert.

No. IC-Green® (indocyanine green for injection) is a sterile product which is injected intravenously or interstitially. This medicinal product is for single patient use only.

When bound to proteins in plasma or in lymph fluid, indocyanine green absorbs light in the near-infrared region with peak absorption at 805 nm and emits fluorescence (light) at a slightly longer wavelength, with peak emission at 830 nm. Fluorescence imaging devices provide external energy as near infrared light for indocyanine green to absorb, resulting in excitation of the indocyanine green, and the emitted light (fluorescence) is transferred from the field of view to an image on a monitor. These optical properties of indocyanine green are utilized in fluorescence imaging of the micro- and macro- vasculature, blood flow and tissue perfusion, the extrahepatic biliary ducts, and for lymphatic mapping of lymph nodes and lymphatic vessels. 

Indocyanine Green for Injection (ICG) is approved for intravenous injection via an injection needle, a central or peripheral catheter or cardiac catheter and also interstitially for lymphatic mapping. 

 IC-Green® Injection (ICG) is a tricarbocyanine dye, is indicated:

• Fluorescence imaging of vessels (micro- and macro-vasculature), blood flow and tissue perfusion before, during and after vascular, gastrointestinal, organ transplant, plastic, micro- and reconstructive surgeries, including generally minimally invasive surgical procedures, in adults and pediatric patients aged 1 month and older
• Fluorescence imaging of extrahepatic biliary ducts in adults and pediatric patients aged 12 years and older
• Fluorescence imaging of lymph nodes and vessels during lymphatic mapping in adults with cervical and uterine cancer
• Ophthalmic angiography in adults and pediatric patients

IC-Green® (indocyanine green for injection)  is approved for use in the USA.

For more information about ICG and how to order, please get in touch with our distributor:

Email: orders@hubrx.com

                                                                                           Phone: (888) 393-3767

To report suspected adverse reactions:

Contact Diagnostic Green LLC at 1-844-424-3784) or FDA at 1-800-FDA-1088 

or www.fda.gov/medwatch

The reconstituted solution should be used within six hours.  It is for single patient use only.  Discard any unused product.