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Frequently
Asked Questions

Verdye, Indocyanine Green (ICG)
Frequently Asked Questions

We’ve put together some commonly asked questions about Verdye, Indocyanine Green and the use of ICG.
If you can’t find the answer to your question please contact us here

Verdye, as it is known in most European territories, is a sterile, lyophilized green powder containing the active ingredient Indocyanine Green (ICG).

 Following intravenous (I.V.) injection, ICG or Indocyanine Green binds rapidly to plasma proteins and remains within the blood vessels. It has a half-life of 3 to 4 minutes and is removed from circulation exclusively by the liver and then eliminated through the bile. It does not undergo metabolism.

Indocyanine Green (ICG) is dissolved using sterile water for injection and is for single use only.

Verdye, Indocyanine Green (ICG), contains up to 5% sodium iodide. Allergic reactions have been reported in patients with and without a history of allergy to iodides. It is known that in very rare cases (<1/10,000), ICG can cause nausea and anaphylactic reactions.

With normal liver function, the plasma half-life of Indocyanine Green (ICG) is 3-4 minutes. Measurements can therefore be repeated after 15-20 minutes.

After I.V. injection, Indocyanine Green (ICG) fluorescence can be visualized in less than one minute.

Verdye, Indocyanine Green (ICG) should be dissolved with sterile water for injection to a final concentration of 5 mg per 1 ml.

The dosage depends on the intended application and the weight of the patient. 

For details, please see the instructions for use at Diagnostic Green Verdye Product Information.

Single dose per measurement in adults, elderly, children

VERDYE IndicationsBonus Injection

Cardiac, Circulatory & Micro-circulatory Diagnostics:

  • Measurement of cardiac output and stroke volume
  • Measurement of circulating blood volumes
0.1 to 0.3 mk/kg body weight

Liver Function Diagnostics:

  • Measurement of excretory function of the liver
0.25 – 0.5 mg/kg body weight

Ophthalmic Angiography Diagnostics:

  • Measurement of perfusion of the choroid
0.1 to 0.3 mg/kg body weight

Total Daily Dose

Age of the patientMax. daily does of ICG
Adults, elderly adolescents (11-18 years)< 5 mg/kg body weight
Children (2 – 11 years)< 1.25 mg/kg body weight
Children (0 – 2 years)< 1.25 mg/kg body weight

Verdye, Indocyanine Green, ICG, is available in packs of 5 Verdye vials.
This applies to all territories outside the USA and Canada and South America.

For more information go to the Product Information Leaflet Diagnostic Green Verdye Product Information.

Verdye Indocyanine Green (ICG) Vials are available in 25mg and 50mg, depending on territory.
For more information go to the Product Information Leaflet Diagnostic Green Verdye Product Information.

No. Indocyanine Green, ICG is a sterile product which is injected intravenously. This medicinal product is for single use only.

Indocyanine Green (ICG) should be reconstituted immediately prior to use. It is for single use only.

After I.V. injection, the Indocyanine Green (ICG) binds rapidly to plasma proteins, of which beta-apolipoprotein B is the principle carrier (95%). It is removed entirely through the liver and then eliminated through the bile. Indocyanine Green, (ICG) is not metabolized or broken down.

Indocyanine Green (ICG) is approved for intravenous injection via an injection needle, a central or peripheral catheter or cardiac catheter.

Verdye (ICG) is a prescription only medicine. Currently, Verdye is approved for:

Cardiac, circulatory and micro-circulatory diagnostics:

  • measurement of cardiac output and stroke volume
  • measurement of circulating blood volumes
  • measurement of cerebral perfusion

Liver function diagnostics:

  • measurement of liver blood flow
  • measurement of excretory function of the liver

Ophthalmic angiography diagnostics:

  • measurement of perfusion of the choroid 

Currently Registered for Distribution

  • Austria
  • Belgium
  • Canada
  • Chile
  • Germany
  • Israel
  • Italy
  • Malta
  • Netherlands
  • Portugal
  • Spain
  • Sweden
  • UK
  • USA

Supplied under Exemption

  • Australia
  • Bahrain
  • Baltic States
  • Belarus
  • Bosnia
  • Croatia
  • Czech Republic
  • Denmark
  • Finland
  • Georgia
  • Greece
  • Hungary
  • Iceland
  • Ireland
  • Luxembourg
  • New Zealand
  • Norway
  • Poland
  • Saudi Arabia
  • Slovenia
  • Singapore
  • South Africa
  • Switzerland
  • Thailand
  • Vietnam
  • UAE

To find a Verdye Distributor or to check the availability of Verdye ICG in your country please go to Verdye Distributors Europe

All territories excluding Americas

All suspected drug reactions and product compliance associated with Verdye Indocyanine Green (ICG) should be reported to:
Email: ICG@drugsafety.de;
Phone: +49 171 3860445;
Email: Diagnostic Green Verdye

Appreciating the travel bans and cancellations of many public events around the world we want our customers to know that we will continue to supply ICG for your hospitals. Our supply chain is very robust and we manage our risk mitigation to ensure we maintain 100% fill rates. So, you can continue to plan and manage your patient procedures with confidence knowing our drug(s) will be available.

Thank you for your business,
From all at Diagnostic Green