Interesting research underway in Illinois Institute of Technology, Canary Ctr. at Stanford for Cancer Early Detection and Thayer School of Engineering at Dartmouth, United States, where they have developed a mathematical framework to estimate patient-specific time-to-maximum contrast after imaging agent administration protocols. Using animal models, they demonstrated that analytical estimates of time-to-maximum contrast in FGS carried out patient-to-patient can outperform the population average time-to-maximum contrast used currently in clinical trials. Such estimates can be made with preoperative DCE-MRI (or similar) and knowledge of the targeted agent’s binding affinity.

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